publications

2026

1. Peptide Design for Targeting BTB Domain Homodimerization of BACH2: Complementary In Silico and In Vitro Approaches

   E. Acar, H. Basaga, E. Timucin, and 1 more author

   ACS Omega, 2026

   Bib

   @article{acar2026peptide,
     title = {Peptide Design for Targeting BTB Domain Homodimerization of BACH2: Complementary In Silico and In Vitro Approaches},
     author = {Acar, E. and Basaga, H. and Timucin, E. and Timucin, A. C.},
     journal = {ACS Omega},
     volume = {11},
     number = {16},
     pages = {24679--24704},
     year = {2026}
   }

2. Pathogenicity Prediction of Missense Variations in Hereditary Cancer Genes

   C. B. Akyerli, G. Gerdan, A. Bülbül, and 3 more authors

   International Journal of Molecular Sciences, 2026

   Bib

   @article{akyerli2026pathogenicity,
     title = {Pathogenicity Prediction of Missense Variations in Hereditary Cancer Genes},
     author = {Akyerli, C. B. and Gerdan, G. and Bülbül, A. and Keskin-Karakoyun, H. and Yüksel, S. K. and Timucin, E.},
     journal = {International Journal of Molecular Sciences},
     volume = {27},
     number = {5},
     year = {2026}
   }

3. Enhanced and Classical MD Simulations Map Aggregation-Prone Regions in the Olfactomedin Domain of Myocilin

   I. Sardag, Z. S. Duvenci, and E. Timucin

   Journal of Chemical Information and Modeling, 2026

   Bib

   @article{sardag2026enhanced,
     title = {Enhanced and Classical MD Simulations Map Aggregation-Prone Regions in the Olfactomedin Domain of Myocilin},
     author = {Sardag, I. and Duvenci, Z. S. and Timucin, E.},
     journal = {Journal of Chemical Information and Modeling},
     volume = {66},
     number = {1},
     pages = {653--667},
     year = {2026}
   }

4. The Pretransplant EASIX Score Predicts Transplant-Related Mortality in Children Undergoing Hematopoietic Stem Cell Transplantation for Non-Malignant Disorders

   V. Uygun, V. Hazar, K. Yalçin, and 8 more authors

   Clinical Transplantation, 2026

   Bib

   @article{uygun2026pretransplant,
     title = {The Pretransplant EASIX Score Predicts Transplant-Related Mortality in Children Undergoing Hematopoietic Stem Cell Transplantation for Non-Malignant Disorders},
     author = {Uygun, V. and Hazar, V. and Yalçin, K. and Öztürkmen, S. and Daloglu, H. and Çelen, S. S. and Zhumatayev, S. and Timuçin, E. and Ildir, S. and Karasu, G. and Yesilipek, A.},
     journal = {Clinical Transplantation},
     volume = {40},
     number = {2},
     year = {2026}
   }

5. Confidence scoring for deep learning-predicted antibody-antigen complexes: AntiConf as a precision-driven metric

   S. Ünsal, B. Holland, I. Sardag, and 1 more author

   Briefings in Bioinformatics, 2026

   Bib

   @article{unsal2026confidence,
     title = {Confidence scoring for deep learning-predicted antibody-antigen complexes: AntiConf as a precision-driven metric},
     author = {Ünsal, S. and Holland, B. and Sardag, I. and Timucin, E.},
     journal = {Briefings in Bioinformatics},
     volume = {27},
     number = {2},
     year = {2026}
   }

2025

1. Determination of the Roles of H. pylori Outer Membrane Virulence Factors and Pyroptosis-Associated NLRP3, ASC, Caspase-1, Gasdermin D, IL-1beta, and IL-18 in Ulcer and Gastritis Pathogenesis

   Y. Buyukcolak-Cebeci, E. Timucin, S. Akcelik-Deveci, and 4 more authors

   Biology (Basel), 2025

   Bib

   @article{buyukcolakcebeci2025determination,
     title = {Determination of the Roles of H. pylori Outer Membrane Virulence Factors and Pyroptosis-Associated NLRP3, ASC, Caspase-1, Gasdermin D, IL-1beta, and IL-18 in Ulcer and Gastritis Pathogenesis},
     author = {Buyukcolak-Cebeci, Y. and Timucin, E. and Akcelik-Deveci, S. and Mansur-Ozen, N. and Aydinlar, T. and Tiftikci, A. and Oktem-Okullu, S.},
     journal = {Biology (Basel)},
     volume = {14},
     number = {6},
     year = {2025}
   }

2. Exploring the role of microbiome in cystic fibrosis clinical outcomes through a mediation analysis

   S. S. Koldas, O. U. Sezerman, and E. Timucin

   mSystems, 2025

   Bib

   @article{koldas2025exploring,
     title = {Exploring the role of microbiome in cystic fibrosis clinical outcomes through a mediation analysis},
     author = {Koldas, S. S. and Sezerman, O. U. and Timucin, E.},
     journal = {mSystems},
     volume = {10},
     number = {6},
     pages = {e0019625},
     year = {2025}
   }

3. Insights into the solution structure of the actin-binding tail domain of metavinculin by small angle X-ray scattering and molecular dynamics simulations

   Z. A. Oztug Durer, H. I. Ince, Z. S. Duvenci, and 5 more authors

   Int J Biol Macromol, 2025

   Bib

   @article{oztugdurer2025insights,
     title = {Insights into the solution structure of the actin-binding tail domain of metavinculin by small angle X-ray scattering and molecular dynamics simulations},
     author = {Oztug Durer, Z. A. and Ince, H. I. and Duvenci, Z. S. and Timucin, E. and Grawert, T. and Orun, O. and Kan, B. and Sayers, Z.},
     journal = {Int J Biol Macromol},
     volume = {319},
     number = {Pt 3},
     pages = {144376},
     year = {2025}
   }

4. AFFIPred: AlphaFold2 structure-based Functional Impact Prediction of missense variations

   M. S. Pir and E. Timucin

   Protein Sci, 2025

   Bib

   @article{pir2025affipred,
     title = {AFFIPred: AlphaFold2 structure-based Functional Impact Prediction of missense variations},
     author = {Pir, M. S. and Timucin, E.},
     journal = {Protein Sci},
     volume = {34},
     number = {2},
     pages = {e70030},
     year = {2025}
   }

5. Computational modeling of the anti-inflammatory complexes of IL37

   I. Sardag, Z. S. Duvenci, S. Belkaya, and 1 more author

   Journal of Molecular Graphics & Modelling, 2025

   Bib

   @article{sardag2025computational,
     title = {Computational modeling of the anti-inflammatory complexes of IL37},
     author = {Sardag, I. and Duvenci, Z. S. and Belkaya, S. and Timucin, E.},
     journal = {Journal of Molecular Graphics & Modelling},
     volume = {136},
     year = {2025}
   }

6. A Novel NUP85 Variant Expanding the Phenotypic Spectrum of NUP85-Associated Steroid-Resistant Nephrotic Syndrome

   E. D. K. Sükür, E. Timucin, T. Bastug, and 1 more author

   Clinical Genetics, 2025

   Bib

   @article{sukur2025novel,
     title = {A Novel NUP85 Variant Expanding the Phenotypic Spectrum of NUP85-Associated Steroid-Resistant Nephrotic Syndrome},
     author = {Sükür, E. D. K. and Timucin, E. and Bastug, T. and Ozaltin, F.},
     journal = {Clinical Genetics},
     volume = {108},
     number = {1},
     pages = {75--79},
     year = {2025}
   }

2024

1. Identification of interaction partners of outer inflammatory protein A: Computational and experimental insights into how Helicobacter pylori infects host cells

   S. Akcelik-Deveci, E. Kilic, N. Mansur-Ozen, and 3 more authors

   PLoS One, 2024

   Bib

   @article{akcelikdeveci2024identification,
     title = {Identification of interaction partners of outer inflammatory protein A: Computational and experimental insights into how Helicobacter pylori infects host cells},
     author = {Akcelik-Deveci, S. and Kilic, E. and Mansur-Ozen, N. and Timucin, E. and Buyukcolak, Y. and Oktem-Okullu, S.},
     journal = {PLoS One},
     volume = {19},
     number = {10},
     pages = {e0300557},
     year = {2024}
   }

2. Rational design of monomeric IL37 variants guided by stability and dynamical analyses of IL37 dimers

   I. Sardag, Z. S. Duvenci, S. Belkaya, and 1 more author

   Comput Struct Biotechnol J, 2024

   Bib

   @article{sardag2024rational,
     title = {Rational design of monomeric IL37 variants guided by stability and dynamical analyses of IL37 dimers},
     author = {Sardag, I. and Duvenci, Z. S. and Belkaya, S. and Timucin, E.},
     journal = {Comput Struct Biotechnol J},
     volume = {23},
     pages = {1854--1863},
     year = {2024}
   }

2023

1. Computational completion of the Aurora interaction region of N-Myc in the Aurora a kinase complex

   P. Altiner, S. S. Cinaroglu, A. C. Timucin, and 1 more author

   Sci Rep, 2023

   Bib

   @article{altiner2023computational,
     title = {Computational completion of the Aurora interaction region of N-Myc in the Aurora a kinase complex},
     author = {Altiner, P. and Cinaroglu, S. S. and Timucin, A. C. and Timucin, E.},
     journal = {Sci Rep},
     volume = {13},
     number = {1},
     pages = {18399},
     year = {2023}
   }

2. Evaluation of AlphaFold structure-based protein stability prediction on missense variations in cancer

   H. Keskin Karakoyun, S. K. Yuksel, I. Amanoglu, and 5 more authors

   Front Genet, 2023

   Bib

   @article{keskinkarakoyun2023evaluation,
     title = {Evaluation of AlphaFold structure-based protein stability prediction on missense variations in cancer},
     author = {Keskin Karakoyun, H. and Yuksel, S. K. and Amanoglu, I. and Naserikhojasteh, L. and Yesilyurt, A. and Yakicier, C. and Timucin, E. and Akyerli, C. B.},
     journal = {Front Genet},
     volume = {14},
     pages = {1052383},
     year = {2023}
   }

3. Follicular homocysteine as a marker of oocyte quality in PCOS and the role of micronutrients

   T. Kucuk, P. E. Horozal, A. Karakulak, and 2 more authors

   J Assist Reprod Genet, 2023

   Bib

   @article{kucuk2023follicular,
     title = {Follicular homocysteine as a marker of oocyte quality in PCOS and the role of micronutrients},
     author = {Kucuk, T. and Horozal, P. E. and Karakulak, A. and Timucin, E. and Dattilo, M.},
     journal = {J Assist Reprod Genet},
     volume = {40},
     number = {8},
     pages = {1933--1941},
     year = {2023}
   }

4. Effect of the switch status of Helicobacter pylori outer inflammatory protein A on gastric diseases

   S. Oktem-Okullu, T. Karaman, S. Akcelik-Deveci, and 5 more authors

   AMB Express, 2023

   Bib

   @article{oktemokullu2023effect,
     title = {Effect of the switch status of Helicobacter pylori outer inflammatory protein A on gastric diseases},
     author = {Oktem-Okullu, S. and Karaman, T. and Akcelik-Deveci, S. and Timucin, E. and Sezerman, O. U. and Mansur-Ozen, N. and Buyukcolak, Y. and Tiftikci, A.},
     journal = {AMB Express},
     volume = {13},
     number = {1},
     pages = {109},
     year = {2023}
   }

5. Brave new surfactant world revisited by thermoalkalophilic lipases: computational insights into the role of SDS as a substrate analog

   M. Shehata, A. Unlu, J. Iglesias-Fernandez, and 3 more authors

   Phys Chem Chem Phys, 2023

   Bib

   @article{shehata2023brave,
     title = {Brave new surfactant world revisited by thermoalkalophilic lipases: computational insights into the role of SDS as a substrate analog},
     author = {Shehata, M. and Unlu, A. and Iglesias-Fernandez, J. and Osuna, S. and Sezerman, O. U. and Timucin, E.},
     journal = {Phys Chem Chem Phys},
     volume = {25},
     number = {3},
     pages = {2234--2247},
     year = {2023}
   }

6. A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers

   Y. Y. Yazici, S. Belkaya, and E. Timucin

   Comput Struct Biotechnol J, 2023

   Bib

   @article{yazici2023small,
     title = {A small non-interface surface epitope in human IL18 mediates the dynamics and self-assembly of IL18-IL18BP heterodimers},
     author = {Yazici, Y. Y. and Belkaya, S. and Timucin, E.},
     journal = {Comput Struct Biotechnol J},
     volume = {21},
     pages = {3522--3531},
     year = {2023}
   }

2022

1. Toward Compilation of Balanced Protein Stability Data Sets: Flattening the DeltaDeltaG Curve through Systematic Enrichment

   N. Kebabci, A. C. Timucin, and E. Timucin

   J Chem Inf Model, 2022

   Bib

   @article{kebabci2022toward,
     title = {Toward Compilation of Balanced Protein Stability Data Sets: Flattening the DeltaDeltaG Curve through Systematic Enrichment},
     author = {Kebabci, N. and Timucin, A. C. and Timucin, E.},
     journal = {J Chem Inf Model},
     volume = {62},
     number = {5},
     pages = {1345--1355},
     year = {2022}
   }

2. Modeling and dynamical analysis of the full-length structure of factor XII with zinc

   E. Kilinc, A. Can Timucin, S. Selim Cinaroglu, and 1 more author

   J Mol Model, 2022

   Bib

   @article{kilinc2022modeling,
     title = {Modeling and dynamical analysis of the full-length structure of factor XII with zinc},
     author = {Kilinc, E. and Can Timucin, A. and Selim Cinaroglu, S. and Timucin, E.},
     journal = {J Mol Model},
     volume = {28},
     number = {5},
     pages = {129},
     year = {2022}
   }

2021

1. Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

   H. H. Le, S. S. Cinaroglu, E. C. Manalo, and 16 more authors

   EBioMedicine, 2021

   Bib

   @article{le2021molecular,
     title = {Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells},
     author = {Le, H. H. and Cinaroglu, S. S. and Manalo, E. C. and Ors, A. and Gomes, M. M. and Duan Sahbaz, B. and Bonic, K. and Origel Marmolejo, C. A. and Quentel, A. and Plaut, J. S. and Kawashima, T. E. and Ozdemir, E. S. and Malhotra, S. V. and Ahiska, Y. and Sezerman, U. and Bayram Akcapinar, G. and Saldivar, J. C. and Timucin, E. and Fischer, J. M.},
     journal = {EBioMedicine},
     volume = {73},
     pages = {103646},
     year = {2021}
   }

2. Bridging the Bridging Imidazolate in the Bimetallic Center of the Cu/Zn SOD1 and ALS

   A. C. Timucin, S. S. Cinaroglu, O. U. Sezerman, and 1 more author

   Front Chem, 2021

   Bib

   @article{timucin2021bridging,
     title = {Bridging the Bridging Imidazolate in the Bimetallic Center of the Cu/Zn SOD1 and ALS},
     author = {Timucin, A. C. and Cinaroglu, S. S. and Sezerman, O. U. and Timucin, E.},
     journal = {Front Chem},
     volume = {9},
     pages = {716438},
     year = {2021}
   }

2020

1. Comprehensive evaluation of the MM-GBSA method on bromodomain-inhibitor sets

   S. S. Cinaroglu and E. Timucin

   Brief Bioinform, 2020

   Bib

   @article{cinaroglu2020comprehensive,
     title = {Comprehensive evaluation of the MM-GBSA method on bromodomain-inhibitor sets},
     author = {Cinaroglu, S. S. and Timucin, E.},
     journal = {Brief Bioinform},
     volume = {21},
     number = {6},
     pages = {2112--2125},
     year = {2020}
   }

2. Understanding thermal and organic solvent stability of thermoalkalophilic lipases: insights from computational predictions and experiments

   M. Shehata, E. Timucin, A. Venturini, and 1 more author

   J Mol Model, 2020

   Bib

   @article{shehata2020understanding,
     title = {Understanding thermal and organic solvent stability of thermoalkalophilic lipases: insights from computational predictions and experiments},
     author = {Shehata, M. and Timucin, E. and Venturini, A. and Sezerman, O. U.},
     journal = {J Mol Model},
     volume = {26},
     number = {6},
     pages = {122},
     year = {2020}
   }

3. Lipase and Water in a Deep Eutectic Solvent: Molecular Dynamics and Experimental Studies of the Effects of Water-In-Deep Eutectic Solvents on Lipase Stability

   M. Shehata, A. Unlu, U. Sezerman, and 1 more author

   J Phys Chem B, 2020

   Bib

   @article{shehata2020lipase,
     title = {Lipase and Water in a Deep Eutectic Solvent: Molecular Dynamics and Experimental Studies of the Effects of Water-In-Deep Eutectic Solvents on Lipase Stability},
     author = {Shehata, M. and Unlu, A. and Sezerman, U. and Timucin, E.},
     journal = {J Phys Chem B},
     volume = {124},
     number = {40},
     pages = {8801--8810},
     year = {2020}
   }

2019

1. Translation and cross-cultural adaptation of the extended version of the Nordic musculoskeletal questionnaire into Turkish

   N. Alaca, E. E. Safran, A. I. Karamanlargil, and 1 more author

   J Musculoskelet Neuronal Interact, 2019

   Bib

   @article{alaca2019translation,
     title = {Translation and cross-cultural adaptation of the extended version of the Nordic musculoskeletal questionnaire into Turkish},
     author = {Alaca, N. and Safran, E. E. and Karamanlargil, A. I. and Timucin, E.},
     journal = {J Musculoskelet Neuronal Interact},
     volume = {19},
     number = {4},
     pages = {472--481},
     year = {2019}
   }

2. Comparative Assessment of Seven Docking Programs on a Nonredundant Metalloprotein Subset of the PDBbind Refined

   S. S. Cinaroglu and E. Timucin

   J Chem Inf Model, 2019

   Bib

   @article{cinaroglu2019comparative,
     title = {Comparative Assessment of Seven Docking Programs on a Nonredundant Metalloprotein Subset of the PDBbind Refined},
     author = {Cinaroglu, S. S. and Timucin, E.},
     journal = {J Chem Inf Model},
     volume = {59},
     number = {9},
     pages = {3846--3859},
     year = {2019}
   }

3. In silico identification of inhibitors targeting N-Terminal domain of human Replication Protein A

   S. S. Cinaroglu and E. Timucin

   J Mol Graph Model, 2019

   Bib

   @article{cinaroglu2019in,
     title = {In silico identification of inhibitors targeting N-Terminal domain of human Replication Protein A},
     author = {Cinaroglu, S. S. and Timucin, E.},
     journal = {J Mol Graph Model},
     volume = {86},
     pages = {149--159},
     year = {2019}
   }

4. Insights into an alternative benzofuran binding mode and novel scaffolds of polyketide synthase 13 inhibitors

   S. S. Cinaroglu and E. Timucin

   J Mol Model, 2019

   Bib

   @article{cinaroglu2019insights,
     title = {Insights into an alternative benzofuran binding mode and novel scaffolds of polyketide synthase 13 inhibitors},
     author = {Cinaroglu, S. S. and Timucin, E.},
     journal = {J Mol Model},
     volume = {25},
     number = {5},
     pages = {130},
     year = {2019}
   }

2018

1. Thermostability of the PYL-PP2C Heterodimer Is Dependent on Magnesium: In Silico Insights into the Link between Heat Stress Response and Magnesium Deficiency in Plants

   E. Timucin and O. U. Sezerman

   J Chem Inf Model, 2018

   Bib

   @article{timucin2018thermostability,
     title = {Thermostability of the PYL-PP2C Heterodimer Is Dependent on Magnesium: In Silico Insights into the Link between Heat Stress Response and Magnesium Deficiency in Plants},
     author = {Timucin, E. and Sezerman, O. U.},
     journal = {J Chem Inf Model},
     volume = {58},
     number = {3},
     pages = {661--672},
     year = {2018}
   }

2016

1. RACK1 Is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy

   S. Erbil, O. Oral, G. Mitou, and 8 more authors

   J Biol Chem, 2016

   Bib

   @article{erbil2016rack1,
     title = {RACK1 Is an Interaction Partner of ATG5 and a Novel Regulator of Autophagy},
     author = {Erbil, S. and Oral, O. and Mitou, G. and Kig, C. and Durmaz-Timucin, E. and Guven-Maiorov, E. and Gulacti, F. and Gokce, G. and Dengjel, J. and Sezerman, O. U. and Gozuacik, D.},
     journal = {J Biol Chem},
     volume = {291},
     number = {32},
     pages = {16753--65},
     year = {2016}
   }

2. Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5

   E. Timucin, A. Cousido-Siah, A. Mitschler, and 2 more authors

   Proteins-Structure Function and Bioinformatics, 2016

   Bib

   @article{timucin2016probing,
     title = {Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5},
     author = {Timucin, E. and Cousido-Siah, A. and Mitschler, A. and Podjarny, A. and Sezerman, O. U.},
     journal = {Proteins-Structure Function and Bioinformatics},
     volume = {84},
     number = {1},
     pages = {129--142},
     year = {2016}
   }

3. Predicting the impact of mutations on the specific activity of Bacillus thermocatenulatus lipase using a combined approach of docking and molecular dynamics

   O. Yukselen, E. Timucin, and U. Sezerman

   J Mol Recognit, 2016

   Bib

   @article{yukselen2016predicting,
     title = {Predicting the impact of mutations on the specific activity of Bacillus thermocatenulatus lipase using a combined approach of docking and molecular dynamics},
     author = {Yukselen, O. and Timucin, E. and Sezerman, U.},
     journal = {J Mol Recognit},
     volume = {29},
     number = {10},
     pages = {466--75},
     year = {2016}
   }

2015

1. Zinc Modulates Self-Assembly of Bacillus thermocatenulatus Lipase

   E. Timucin and O. U. Sezerman

   Biochemistry, 2015

   Bib

   @article{timucin2015zinc,
     title = {Zinc Modulates Self-Assembly of Bacillus thermocatenulatus Lipase},
     author = {Timucin, E. and Sezerman, O. U.},
     journal = {Biochemistry},
     volume = {54},
     number = {25},
     pages = {3901--10},
     year = {2015}
   }

2014

1. Direct in vitro selection of titanium-binding epidermal growth factor

   S. Tada, E. Timucin, T. Kitajima, and 2 more authors

   Biomaterials, 2014

   Bib

   @article{tada2014direct,
     title = {Direct in vitro selection of titanium-binding epidermal growth factor},
     author = {Tada, S. and Timucin, E. and Kitajima, T. and Sezerman, O. U. and Ito, Y.},
     journal = {Biomaterials},
     volume = {35},
     number = {11},
     pages = {3497--503},
     year = {2014}
   }

2013

1. Modifying the catalytic preference of tributyrin in Bacillus thermocatenulatus lipase through in-silico modeling of enzyme-substrate complex

   E. Durmaz, S. Kuyucak, and U. O. Sezerman

   Protein Eng Des Sel, 2013

   Bib

   @article{durmaz2013modifying,
     title = {Modifying the catalytic preference of tributyrin in Bacillus thermocatenulatus lipase through in-silico modeling of enzyme-substrate complex},
     author = {Durmaz, E. and Kuyucak, S. and Sezerman, U. O.},
     journal = {Protein Eng Des Sel},
     volume = {26},
     number = {5},
     pages = {325--33},
     year = {2013}
   }

2. The Conserved Lid Tryptophan, W211, Potentiates Thermostability and Thermoactivity in Bacterial Thermoalkalophilic Lipases

   E. Timucin and O. U. Sezerman

   Plos One, 2013

   Bib

   @article{timucin2013conserved,
     title = {The Conserved Lid Tryptophan, W211, Potentiates Thermostability and Thermoactivity in Bacterial Thermoalkalophilic Lipases},
     author = {Timucin, E. and Sezerman, O. U.},
     journal = {Plos One},
     volume = {8},
     number = {12},
     year = {2013}
   }

2011

1. The drought response displayed by a DRE-binding protein from Triticum dicoccoides

   S. Lucas, E. Durmaz, B. A. Akpinar, and 1 more author

   Plant Physiol Biochem, 2011

   Bib

   @article{lucas2011drought,
     title = {The drought response displayed by a DRE-binding protein from Triticum dicoccoides},
     author = {Lucas, S. and Durmaz, E. and Akpinar, B. A. and Budak, H.},
     journal = {Plant Physiol Biochem},
     volume = {49},
     number = {3},
     pages = {346--51},
     year = {2011}
   }